GENERATION OF AN INDUCED PLURIPOTENT STEM CELL LINE (TRNDI005-A) FROM A MUCOPOLYSACCHARIDOSIS TYPE IVA (MPS IVA) PATIENT CARRYING COMPOUND HETEROZYGOUS P.R61W AND P.WT405DEL MUTATIONS IN THE GALNS GENE

Mucopolysaccharidosis type IVA (MPS IVA) Lip Tint is a rare genetic disease caused by mutations in the GALNS gene and is inherited in an autosomal recessive manner.GALNS encodes N-acetylgalactosamine-6-sulfatase that breaks down certain complex carbohydrates known as glycosaminoglycans (GAGs).Deficiency in this enzyme causes accumulation of GAGs in

The rail network is essential for sustainable transportation, offering various advantages such as reduced greenhouse gas emissions and congestion relief.However, ensuring safety within the rail network is crucial for its long-term viability and public acceptance.Derailment incidents have significant implications for safety, efficiency, and sustaina

Silymarin is the extract of Silybum marianum, or Alarm Clocks milk thistle, and its major active compound is silybin, which has a remarkable biological effect.It is used in different liver disorders, particularly chronic liver diseases, cirrhosis and hepatocellular carcinoma, because of its antioxidant, anti-inflammatory and antifibrotic power.Inde

Abstract Background Immunization has been an important public health intervention for preventing and reducing child morbidity and mortality over the years and coverage has increased in the past decades.However, the validity of the data from immunization coverages is usually disputed.Immunization data from health facilities show poor concordance bet